![]() ![]() 608E/W (Louisa County) to Belsches Rd Clearview Ln Hill Dr Hillside Ln Lewis Hill Ln Locust Hill Ln Rt. 654N (Louisa County) from Cedar Post Ranch Rd Eastview Ln Mckinney Ln Parsons Rd Rabbit Run Rd Signboard Rd Walters Way Rt. The west right shoulder is an alternating closure. The east right shoulder is an alternating closure. On I-64 in the County of Louisa at mile marker 143, motorists can expect potential delays in this area from 06/08/23 at 8:00 AM until 06/08/23 at 4:00 PM due to roadside maintenance. Planned Event - WZ - Maintenance - Shoulder Repairs On I-64 in the County of Louisa from mile marker 131.2 to mile marker 138, motorists can expect potential delays in this area from 06/09/23 at 7:00 AM until 06/09/23 at 4:00 PM due to maintenance activities. I-64E from MM 131.2 to MM 138.0 View on Map Planned Event - WZ - Maintenance - Tree Removal Operations The south left shoulder and right shoulder are mobile closures. The north left shoulder and right shoulder are mobile closures. On I-81 in the County of Frederick from mile marker 304 to mile marker 323, motorists can expect potential delays in this area from 06/08/23 at 8:00 AM until 06/08/23 at 4:00 PM due to roadside maintenance. I-81N from MM 304.0 to MM 323.0 View on Map Planned Event - WZ - Bridge - Bridge Substructure Repairs 637N/S (Greene County), motorists can expect potential delays in this area from 05/19/23 at 7:00 AM until 12/15/23 at 5:00 PM due to bridge work. 638 (Turkey Ridge Rd) in the County of Greene from Bull Yearling Rd Rt. 638E (Greene County) at Turkey Ridge Rd View on Map ![]()
0 Comments
![]() the biggest battle since Appomattox and the most considerable engagement American troops had ever had with a foreign enemy." The battle was such a hard-won success it led General Pershing to say, "The deadliest weapon in the world is a Marine and his rifle!" and that "the Battle of Belleau Wood was for the U.S. Advancing against well-emplaced German machine gun positions and suffering heavy losses, the Marines managed to push the Germans back and take their objectives. The battle lasted a month and was fought often times with bayonets. After years of deadlock, Germany launched their last desperate spring offensive, annihilating the British 5th Army and getting within 40 miles of Paris. ![]() Russia had the Bolshevik revolution and left the war, freeing fifty German divisions to move from the Eastern Front and turn against France. Taking place in June of 1918, the Battle of Belleau Wood was strategically important. The conduct of the Sixth and Fifth Marines here made the Corps legendary. The Battalion participated in numerous battles, but the one that is most remembered was the battle of Belleau Wood. The First Battalion Sixth Marines was formed 11 July 1917 and was quickly deployed to France between September and October of that year. ![]() When WWI began the Marine Corps was expanded in order to support the American Expeditionary Force being sent to support the Allied Powers under General Pershing. ![]() Its mission was limited to providing ships detachments and was considered by many as an anachronism of the days of sail. The Corps was a small and underappreciated force before the eruption of World War I. The history of 1/6 Hard is closely tied with the history of the United States Marine Corps. ![]() ![]() This article has been updated to reflect these changes. Note: empire approval modifiers changed drastically with the release of the Disharmony expansion. Ideally you want to avoid this high dust usage altogether - if not, establishing trade with an ally can help avoid needing to do this. This links approval to military might - the more you fight, the more dust you need for ships. The second is tax rate: high taxes mean low approval. Therefore the rate of expansion should keep pace with technologies that reduce maluses and increase approval. Especially notable are high-class planets - especially lava/barren or above, which increase disapproval significantly. Every system that is colonized will add some disapproval through population growth or system count. The single main conscious decision factor is expansion and colonization. Ideally you will keep your approval in the good-ferverent area on planets that are growing or are industrial planets. ![]() ![]() It is important to balance and account for all the factors that influence approval, and keep the rating as high as possible (while not limiting the empire in any area). Low approval rates will decrease production of every one of the FIDS, slowing growth. With a bad rating, your empire is likely to literally go on strike. How the approval system works, and how to keep approval as high as possible, are questions asked quite often. Managing approval is a crucial part of playing Endless Space. Endless Space approval system - basic tutorial ![]() ![]() ![]() Pereira AV, de Barros G, Pinto EG et al.Springer Science & Business Media, New York 2014 25-43. Paratransgenic Control of Leishmaniasis: New Developments. Hurwitz I, Forshaw A, Yacisin K, Ramalho-Ortigao M, Satoskar A, Durvasula R.Formatex Research Center, Badajoz 2015 137-43. The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs. Development of antimicrobial peptide based anti-leishmanial agents: current understandings and future perspective. Melittin-Containing Hybrid Peptide Hydrogels for Enhanced Photothermal Therapy of Glioblastoma. Melittin inhibits tumor growth and decreases resistance to gemcitabine by downregulating cholesterol pathway gene CLU in pancreatic ductal adenocarcinoma. Preparation and functional characterization of human vascular endothelial growth factor-melittin fusion protein with analysis of the antitumor activity in vitro and in vivo. Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma. Melittin exerts an antitumor effect on non‑small cell lung cancer cells. ![]() Melittin suppresses tumor progression by regulating tumor-associated macrophages in a Lewis lung carcinoma mouse model. Lee C, Choi D, Lee S, Sung-joo SB, Joo H, Bae H.Melittin inhibits the invasion of MCF‑7 cells by downregulating CD147 and MMP‑9 expression. ![]() Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. Anti‐cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF‐κB. Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-κB and AP-1-dependent MMP-9 expression. Nan Fang Yi Ke Da Xue Xue Bao 2007 27: 1775-77. Melittin inhibits proliferation and induces apoptosis of malignant human glioma cells. Effect of polypeptides in bee venom on growth inhibition and apoptosis induction of the human hepatoma cell line SMMC‐7721 in‐vitro and Balb/c nude mice in‐vivo. Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy.
![]() ![]() ![]() If you want more Witcher content, check out our other articles here and here.Contains mild spoilers for The Witcher season 1 There’s also a prequel series, The Witcher: Blood Origins, on the table. There’s enough material in the books, and even the video games (though they are non cannon) to carry on Geralt and friends for more monster slaying adventures around the Continent. Greenlit back in September 2021, The Witcher will be back for a third season and possibly plans to stick around for a full seven seasons on Netflix. You have that opportunity to go back and course correct if you want to.” The Witcher Season 3 has already been greenlit plus more Hissrich told Flickering Myth’s Writer Experiencepodcast that, “the Nilfgaard armor will be totally different. The wrinkly Nilfgaardian armor, which some fans on the internet didn’t like, will be upgraded in The Witcher season 2. Some other changes are coming next year, too. But, I do want to employ some different ways to look at time series-wide.” IMAGE VIA GOOGLE It’s not like all three are together and happy all the time. According to showrunner Lauren S Hissrich, “the stories will be told in a much more linear fashion. Indeed, this season will mark the first time Freya Allan and Anya Chalotra have actually acted together, which should make things easier to follow. Where Season 1 focused on multiple timelines, telling each character’s individual story in different episodes, Season 2 sees these timelines now converged and will be told simultaneously. Geralt – a man who rarely uses words when a grunt will do – might even become a bit more talkative in his new paternal role. It’s a season about Geralt becoming a father figure to Ciri, according to showrunner Lauren S Hissrich, so expect that relationship to drive season 2. While the Continent’s kings, elves, humans, and demons strive for supremacy outside its walls, he must protect the girl from something far more dangerous: the mysterious power she possesses inside. Picking up after the events of Season 1, believing that Yennefer has lost her life at the Battle of Sodden, Geralt has taken Princess Cirilla to his home, the Witcher stronghold of Kaer Morhen, where in the hopes to protect her, trains her in the ways of the Witcher. Freya Allan as Ciri, the Lion Cub of Cintra.Anya Chalotra as Yennefer of Vengerberg.IMAGE VIA GOOGLE The Witcher Season 2 Cast: Returning and New Voleth Meir is reportedly elven for ‘Deathless Mother’, and it seems the character has an important role to play in Ciri’s arc. And ‘Voleth Meir’ refers to a new character played by Ania Marson. ‘Dear Friend’ presumably refers to a letter Geralt wrote to Yennefer in the Witcher books. ‘Redanian Intelligence’ refers to Redania, a country on the Continent that possesses an exceptional spy network– maybe we’ll even meet a certain Redanian spy. ‘Kaer Morhen’ is the name of a fortress where Witchers are trained. ‘A Grain of Truth’ takes its name from a short story in Andrzej Sapkowki’s book The Last Wish, which features Nivellen, the character played by Game of Thrones’ Kristofer Hivju in The Witcher season 2. The episode titles offer up a few clues about The Witcher season 2. The final episode title is so secret, we’ll have to wait and see when December 17th hits. IMAGE VIA GOOGLE IMAGE VIA GOOGLE The Witcher Season 2 episode Titles have bee Revealed: Released on August 23rd, 2021, Nightmare of the Wolf gives Vesimir’s backstory from his hey-days as a young Witcher before the events in Season 1. If you have yet to watch Netflix’s The Witcher: Nightmare of the Wolf, watch it. Joining the cast is our favorite ax wielding Wildling, Kristofer Hivju as the Beast Nivellen from Sapkowski’s The Last Wish and Kim Bodania as Vesemir, Geralt’s Witcher mentor. With more Witchers, more magic, more double-crossing, and more political intrigue on the menu, this season is set to be just as essential as the first. With the complex multiple timelines of the first season now aligned, The Witcher season 2 unites Geralt with orphaned princess Ciri (Freya Allan) on their way to the School of the Wolf’s headquarters, Kaer Morhen, and you can guarantee it won’t be too long before they cross paths with the show’s third viewpoint character, the enchantress known as Yennefer of Vengerberg (Anya Chalotra). Yet, never fear, the cast and crew have put on their best to bring us this masterpiece from the pages of Andrezj Sapkowski’s Witcher series.Īs expected, movie Superman Henry Cavill returns as the eponymous monster-hunting Witcher, Geralt of Rivia, continuing his adventures across the vast world of the Continent. ![]() ![]() It’s been awhile since Season 1 arrived back in 2019 and production has been slow for season 2 with Covid still raging and regulations have been put through. ![]() ![]() 626 El Rèquiem de Mozart Requiem mozart El Requiem de Mozart Mozartin requiem Requiem d-molli, KV 626 Requiem d-molli Requiem (Mozart) Rekvijem Wolfgang Amadeus Mozart: Rekvijem Mozart's Requiem Rekviema Meso en D-minoro Requiem in re minore Requiem ta' Mozart 19 Requiem di Mozart Messa di Requiem Mozart Requiem モツレク Mozart-Requiem lyric Mozarts Requiem Реквием Моцарт Re Minör Requiem Requiem Mass in D minor Rèquiem de Mozart Rèquiem K. 18 K 626 Misa n 18 Réquiem de Mozart Misa n 19 Lacrimosa Misa de requiem en re menor Misa n º 19 Misa n.
![]() ![]() It also adds in recommended workout content, making Whoop an active part of your training for the first time. Whoop has also just added a muscular strain score, which offers insight into the recovery required by your body. You can also see your live heart rate, perfect for HIIT. In our experience, the best results happen when you wear it on your bicep for workouts.įrom there, it will track your heart rate during a workout, attributing a 'Strain' score to the session so you know how hard you've pushed yourself. The Whoop 4.0 is a heart rate monitor you wear 24/7 on your wrist, on your upper arm, and even in gym gear through Whoop's official Body garments. It's all about tracking strain and recovery between workouts – making sure you sleep, rest, and recover enough between sessions and smash it when Whoop (literally) gives you the green light. Its focus isn't on tracking metrics like distance or reps. The Whoop 4.0 is a supremely useful wearable for HIIT training or CrossFit, and pretty much every kind of workout you can imagine. Price when reviewed: $25 a month subscription That's because your heart rate will tell you if you're pushing yourself hard enough during your intense intervals and will let you know how much you've recovered during the rest intervals. If you're training using High-Intensity Interval Training (HIIT) methods, it's the heart rate that's your primary concern. Best watch for weights/ HIIT and strength training Most wearables designed for the gym will be worn on the wrist, but there are options out there that will let you move the key tracking sensors around the body whether it's attached with other accessories or you can actually place it inside of clothes and still get that reliable hit of tracking data. Some devices will let you connect to single or multiple devices, letting you see real-time stats on indoor trainers or another smart gym kit. It's also useful to have a wearable that can share and transmit data to other connected gym equipment and the key to that is having something that offers ANT+ or Bluetooth smart connectivity. Check if the wearable can be connected to other apps outside of the main one you'll need to set it up and sync data to. ![]() It can be useful to take any data a wearable can record and collate it inside of other training-focused apps like Strava or TrainingPeaks where you'll get an alternative breakdown of data and start to see how it sits with your other non-gym-based training. A lot of watches will say they can track a session of push-ups, but few track that movement and focus on capturing workout duration and heart rate data. Gym wearable key considerations: Check what and how it tracksĪ lot of wearables promise to track a range of activities but few offer the ability to track metrics specific to those activities. This heart rate monitor chest strap that works for all workouts is made for cyclists, capturing cycling metrics like cadence and offering the kind of connectivity to hook it up to multiple devices. Best wearable for spinning/indoor cycling: Wahoo Tickr X – Full review. ![]() The company has also just unveiled a new strain score specifically for muscular recovery, making it the first truly recommendable gym wearable. The Whoop's focus on recovery makes it a perfect companion for HIIT sessions, CrossFit, and strength training. Best wearables for HIIT training: Whoop 4.0 – Full review.Whether you're a die-hard gym bunny that loves spinning, or you're just looking for a way to add accurate information from your sessions to your daily activity tracking, there are wearables out there to better suit you.īelow are some of our favorite wearable gym aids, whether it's for HIIT, weights, spinning, treadmill training, CrossFit, and even boxing. ![]() The latest gym-focused wearables can guide you on your form, exertion, and reps to help you get the best results faster – and focus on the recovery you need to hit your goals. Fitness trackers and smartwatches have been notoriously underwhelming for gym-goers, but there's a new breed of wearables designed for strength, Crossfit, HIIT, and gym-based workouts. ![]() ![]() ![]() But none of them do it for free, do it as fast, and do it as simply as PDF Expert. ![]() Of course, nearly all the best PDF apps on the iPad can now perform basic (and even complex) document merges. PDF Expert 6 was the only app that could merge PDFs in our last round of testing. Through numerous review iterations, PDF Expert has surprised us time and again - the last time this review was updated, PDF Expert introduced a new categorical feature all by itself. PDF Expert has been our pick for the best PDF app on iPad since the early days in 2013. And above all, PDF Expert offered more features inside its free toolsets - such as the ability to merge PDFs - than all other PDF apps. There were many apps that could do almost every task, but often fell short in one or more tests - most notably in the merging and form-filling tests. In almost every task, PDF Expert performed faster and/or more reliably than the other PDF apps we tested. Only one PDF app, PDF Expert 6, could do all of those tasks. Syncing PDF documents between devices/services.Redacting, highlighting, adding text, and notating PDFs.Compatibility with the different annotations and forms.We imported all three documents into each PDF app and ran the following tests: We also utilized a 500-page general ledger PDF document as a dummy unit for testing document merge speeds. Our testing for each PDF app involved working with three PDF files: a fillable PDF form containing a basic rent application, one annotated PDF app, and one seven-page legal-sized scanned lease that had OCR applied to it on scanning. Many apps have been discontinued since 2013 or have seen major updates. Which PDF apps we tested, and how we tested themįor our testing, we included both paid and free apps that were popular or recommended. PDFs are the most reliable way to do this, and are an important part of any serious iPad user’s workflow. This is a boon for design-minded people who want to ensure that invoices, contracts, proposals, and brochures come across looking perfect, regardless of what device they’re viewed on. They will help you get the most out of your devices and your day. And they range across several different categories but are mostly focused on productivity. These apps work on iPad, iPhone, and Mac. A hidden feature of each app that you may not have known about.A special, pro tip for each app to help you save time and become more of a power user.The current list of The Sweet Setup’s top 8, must-have apps.Our team here at The Sweet Setup put together a short list of our must-have, most-used apps in 2022. We spend an inordinate amount of time sorting through hundreds of apps to find the very best. Almost any computing device can view them, and they will almost always display as intended - with formatting and layout intact - across all manner of platforms and devices. PDFs happen to be one of the best and most universal ways to send a document to another person. For many students, PDFs are the future’s version of last year’s textbook. For many professional-based businesses - such as accounting, law, and realty firms - PDFs are a necessary evil. In most cases, PDF Expert’s free toolset outmatches other for-pay options.įor almost any contract-based business, PDFs are a way of life. PDF Expert is delightfully easy to use, offers the fastest PDF app reading experience, works with many syncing services, and has the most robust toolset available on the iPad. But make no mistake - PDF Expert 6 is still the best app for managing, editing, and viewing PDFs on the iPad. Many apps have come and gone, while others have debuted and given PDF Expert a run for its money. PDF Expert took the crown way back in 2013 and PDF Expert continues to be the very best PDF option for iPads in 2021 and beyond. Ben Brooks originally slogged through seventeen different PDF apps to find the best PDF app for managing, editing, and reading PDFs on the iPad. ![]() ![]() ![]() Quixel Mixer makes it exceptionally easy to import and export models between your favourite programs using the also absolutely free Quixel Bridge this includes the following. While a PBR workflow itself supports a large amount of render engines. Supports Large Array of Render and Game Engines Using the previous example you can adjust how much dirt you want and its color. Further to that Smart Materials have multiple parameters you can adjust to get your model looking exactly how you want it to. ![]() This saves you having to manually apply such detail yourself, saving a lot of time. While regular textures are simply a image a Smart Material is programmed to adapt and change to a model.įor example if you want to apply dirt to your model the smart materials may detect the crevices of your model and apply larger amounts of dirt in those areas that may not be as easily cleaned. ![]() Quixel Mixer has a library of approximately 400 and increasing Smart Materials you can use for free.Ī Smart Material is different to regular texture is the way that it functions. If you are interested in how PBR works I recommend you check out this article I wrote explaining what a 3d artist should know without the technical side. Knowing what the finished product will look as expected is a huge time saver. This is a huge advantage as it greatly improves your workflow. Meaning what the model looks like is consistent across different render and game engines, without the need to adjust engine specific shaders. It produces standard texture sets that a large number of 3D software use. PBR is more or less the standard when it comes to texturing nowadays. Some basic knowledge on how the program works and PBR itself is beneficial. This doesn’t mean it is something you can just use competently. The fact it has less functionality is one of its best advantages, as it means the user interface isn’t cluttered with buttons. The Megascans library is free provided you are using it for projects within Unreal Engine anything else you are required to pay a subscription. The only exception is if you choose to utilize the Quixel Megascans library which is an addition to the 400 free smart materials you are provided. Quixel Mixer is completely free for use in personal and commercial projects.
![]() ![]() The game's multiplayer mode was criticised, as it was plagued by lag and inaccurate tracking of statistics. The story of the game's single player campaign focuses on a war in the 24th century between two factions, one human and the other alien, that is interrupted in its fourteenth year by the arrival of an enigmatic and militant alien race, whose genocidal advance forces the two sides into a ceasefire in order to work together to halt the threat.ĭescent: FreeSpace was well-received as a single-player space simulation that integrated all the desired features of its genre, from competent AI wingmen, to the presence of large capital ships that dwarf the fighters piloted by the player and explode spectacularly when destroyed. The game places players in the role of a human pilot, who operates in several classes of starfighter and combats against opposing forces, either human or alien, in various space-faring environments, such as in orbit above a planet or within an asteroid belt. ![]() ![]() In 2001, it was ported to the Amiga platform as FreeSpace: The Great War by Hyperion Entertainment. Descent: FreeSpace – The Great War, known as Conflict: FreeSpace – The Great War in Europe, is a 1998 space combat simulation IBM PC compatible computer game developed by Volition, when it was split off from Parallax Software, and published by Interplay Productions. ![]() |